HOME Prof. Dr. Len COLL. RESEARCH PUBLICATIONS

2018

R.S. Varma, C. Len. Recent advances in glycerol valorization in continuous flow process. Curr. Opin. Green Sustain. Chem. 2018, in press.

Y. Wang, P. Prinsen, K.S. Triantafyllidis, S.A. Karakoulia, A. Yepez, C. Len, R. Luque. Batch vs continuous flow performance of supported mono- and bimetallic nickel catalysts for catalytic transfer hydrogenation of furfural in isopropanol. ChemCatChem. 2018, 10, 3459-3468.

Y. Wang, P. Prinsen, K.S. Triantafyllidis, S.A. Karakoulia, P.N. Trikalitis, A. Yepez, C. Len, R. Luque. Comparative study of supported monometallic catalysts in the liquid-phase hydrogenation of furfural : batch and continuous flow. ACS Sustainable Chem. Eng. 2018, 6, 9831-9844.

W. Ouyang, D. Zhao, Y. Wang, A. Balu, C. Len, R. Luque. Continuous flow conversion of biomass-derived methyl levulinate into gamma valerolactone using functional metal organic framework. ACS Sustainable Chem. Eng. 2018, 6, 6746-6752.

D. Zhao, P. Prinsen, Y. Wang, W. Ouyang, F. Delbecq, C. Len, R. Luque. Continuous flow alcoholysis of furfuryl alcohol to alkyl levulinates using zeolites. ACS Sustainable Chem. Eng. 2018, 6, 6901-6909.

F. Delbecq, Y. Wang, A. Muralidhara, K. El Ouardi, G. Marlair, C. Len. Hydrolysis of hemicellulose and derivatives – A review of recent advances in the production of furfural. Front. Chem. 2018, 6, 146.

S. Tadrent, D. Luart, O. Bals, A. Khelfa, R. Luque, C. Len. Metal-free reduction of nitrobenzene to aniline in subcritical water. J. Org. Chem. 2018, 83, 7431-7437.

F. Delbecq, C. Len. Recent advances in the microwave-assisted production of hydroxymethylfurfural by hydrolysis of cellulose derivatives – a review. Molecules 2018, 23, 1973-1988.

F. Delbecq, Y. Wang, A. Muralidhara, K. El Ouardi, G. Marlair, C. Len. Hydrolysis of hemicellulose and derivatives – A review of recentadvances in the production of furfural. Front. Chem. 2018, 6, 146.

K. Danoun, Y. Essamlali, O. Amadine, R. Tabit, A. Fihri, C. Len, M. Zahouily. Nanostructured pyrophosphate Na 2 PdP 2 O 7 : a highly efficient and recyclable catalyst for the Suzuki-Miyauracouplingundermicrowave irradiation. Appl. Organometal. Chem. 2018, 32, e4232.

H. Maati, O. Amadine, Y. Essamlali, A. Fihri, A. Rhihil, C. Len, M. Zahouily. Nanostructured zirconium pyrophosphate catalyzeddiastereoselectivesynthesis of b -aminoketones via one-pot three-component Mannichreaction. Catal. Letters 2018, 148, 699-711.

S. Bruniaux, D. Luart, C. Len. Continuous flow reductive alkylation: synthesis of bio-based symmetrical and dissymmetricalethers. Synthesis, 2018, 50, 1849-1856.

F. Delbecq, Y. Takahashi, T. Kondo, C.C. Corbas, E.R. Ramos, C. Len. Microwave assisted efficient furfural production using nano-sized surface-sulfonateddiamondpowder. Catal. Commun. 2018, 110, 74-78.

C. Len, F. Delbecq, C.C. Corpas, E.R. Ramos. Continuous flow conversion of glycerol into chemicals : an overview. Synthesis 2018, 50, 723-740.

Y. Wang, F. Delbecq, R.S. Varma, C. Len. Comprehensive study on expeditious conversion of pre-hydrolyzed alginic acid to furfural in Cu(II) biphasic systems using microwaves. Mol. Catal. 2018, 445, 73-79.

C. Chao, C. Genot, C. Rodriguez, H. Magniez, S. Lacourt, A. Fievez, C. Len, I. Pezron, D. Luart, E. Van Hecke. Emollients for cosmetic formulations: towards relationships between physico-chemical properties and sensory perceptions. Colloids Surf. A Physicochem. Eng. Asp. 2018, 536, 156-164.

F. Mangin, P. Prinsen, A. Yepez, M. Rehan, H.S. Gilani, G. Xu, C. Len, R. Luque. Microwave assisted benzyl alcohol oxidation using iron particles on furfuryl alcohol derived supports. Catal. Commun. 2018, 104, 67-70.

2017

R. Nguyen, J. Castello, I. Pezron, D. Luart, E. Van Hecke, C. Len. Efficient synthesis, calorimetric and rheological studies of symmetrical bio-based fatty ethers. Ind. Eng. Chem. Res. 2017, 56, 10329-10334.

Y. Essamlali, O. Amadine, M. Larzek, C. Len, M. Zahouily. Sodium modified hydroxyapatite : highly efficient and stable solid-base catalyst for biodiesel production. Energy Convers. Manage. 2017, 149, 355-367.

A. Fihri, C. Len, R.S. Varma, A. Solhy. Hydroxyapatite: a review of syntheses, structure and applications in heterogeneous catalysis. Coord. Chem. Rev. 2017, 347, 48-76.

Y. Wang, F. Delbecq, W. Kwapinski, C. Len. Application of sulfonated carbon-based catalyst for the furfural production from D-xylose and xylan in a microwave-assisted biphasic reaction. Mol. Catal. 2017, 438, 167-172.

M. Billamboz, C. Imbs, E. Banaszak-Leonard, C. Len. Selective one-pot-three-steps cascade reaction : from aromatic aldehydes to 2,2-diphenylethanol derivatives. Org. Process Res. Dev. 2017, 21, 835-843.

S. Malhotra, S. Singh, N. Rana, S. Tomar, P. Bhatnagar, M. Gupta, S.K. Singh, B.K. Singh, A.K. Chhillar, A.K. Prasad, C. Len, P. Kumar, K.C. Gupta, A.J. Varma, R.C. Kuhad, G.L. Sharma, V.S. Parmar, N.G.J. Richards. Chemoenzymatic synthesis, nanotization and anti-Aspergillus activity of optically enriched fluconazole analogues. Antimicrob. Agents Chemother. 2017, 61, e00273.

C. Len, S. Bruniaux, F. Delbecq, V.S. Parmar. Palladium-catalyzed Suzuki-Miyaura cross-coupling in continuous flow. Catalysts 2017, 7, 146-168.

R. Nguyen, N. Galy, A. Singh, F. Paulus, D. Stoebener, C. Schlesser, S.K. Sharma, R. Haag, C. Len. A simple and efficient process for large scale glycerol oligomerization by microwave irradiation. Catalysts 2017, 7, 123-134.

A. Mazière, A. Garcia, P. Prinsen, R. Luque, C. Len. A review on progress in catalytic routes from and to renewable succinic acid. BioFPR 2017, 11, 908-931.

N. Galy, R. Nguyen, P. Blach, S. Sambou, D. Luart, C. Len. Glycerol oligomerization in continuous flow reactor. J. Ind. Eng. Chem. 2017, 51, 312-318.

A. J. Garcia-Olmo, A. Yepez, A. M. Balu, P. Prinsen, A. Garcia, A. Mazière, C. Len, R. Luque. Activity of continuous flow synthesized Pd-based nanocatalysts in the flow hydroconversion of furfural. Tetrahedron 2017, 73, 5599-5604.

F. Delbecq, Y. Wang, C. Len. Various carbohydrate precursors dehydration to 5-HMF in an acidic biphasic system under microwave heating using betaine as a co-catalyst. Mol. Catal. 2017, 434, 80-85.

K. Venkateswaran, A. Verma, A.N. Bhatt, A. Shrivastava, K. Manda, H.G. Raj, A.K. Prasad, C. Len , V.S. Parmar, B. S. Dwarakanath. Emerging roles of calreticulin incancer: Implications for therapy. Curr. Protein Pept. Sci. 2017, in press. DOI : 10.2174/1389203718666170111123253.

P. Kumar, A. Matta, S. Singh, J. Van der Eycken, C. Len, V.S. Parmar, E.V. Van der Eycken, B.K. Singh. Facile, catalyst-free microwave-assisted access toward the synthesis of 2-aryl/alkyl-3-(1H-benzo[d]imidazol-2-yl)-2,3-dihydroquinazolin-4(1H)-ones. Synth. Commun. 2017, 47, 756-763.

C. Cazorla, M. Billamboz, H. Bricout, E. Monflier, C. Len. Green and scalable palladium on carbon-catalyzed Tsuji-Trost coupling reaction using an efficient and continuous flow system. Eur. J. Org. Chem. 2017, 6, 1078-1085.

S. Verma, N. Baig, M. N. Nadagouda, C. Len, R. S. Varma. Sustainable pathway to furanics from biomass via heterogeneous organo-catalysis. Green Chem. 2017, 19, 164-168.

Y. Wang, T. Len, Y. Huang, A. D. Tabaoda, A. N. Boa, C. Ceballos, F. Delbecq, G. Mackenzie, C. Len. Sulfonated Sporopollenin as an efficient and recyclable heterogeneous catalyst for dehydration of D-xylose and xylan into furfural. ACS Sustainable Chem. Eng. 2017, 5, 392-398.

I. Polaert, L. Estel, D. Luart, C. Len, M. Delmotte. A new and original microwave continuous reactor under high pressure for future chemistry. AIChE Journal 2017, 63, 192-199.

2016

P. K. Sharma, D. Mathur, S. Malhotra, N. Rana, B. K. Singh,A. K. Prasad, A. J. Varma, N.A. Shakil, B. Ghosh, C. Len, R. C. Kuhad, F. Jerome, V. S. Parmar. Triphenyl phosphite-mediated green synthesis of novel carboxycoumarin amides. Curr. Green Chem. 2016, 3, 366-373.

N. Sotto, C. Cazorla, C. Villette, M. Billamboz, C. Len. Selective pinacol-coupling reaction using a continuous flow system. J. Org. Chem. 2016, 81, 11065-11071.

N. Sotto, C. Cazorla, C. Villette, M. Billamboz, C. Len. Toward the sustainable synthesis of biosourced divinylglycol from glycerol. ACS Sustainable Chem. Eng. 2016, 4, 6996-7003.

A. Kumar,A. Khan,S. Malhotra,R. Mosurkal,A. Dhawan,M.K. Pandey, B.K. Singh,R. Kumar,A.K. Prasad, S.K. Sharma,L.A. Samuelson,A.L. Cholli, C. Len,N.G.J. Richards, J. Kumar,R. Haag, A.C. Watterson,V.S. Parmar. Synthesis of macromolecular systems  via  lipase catalyzed biocatalytic reactions: Applications and future perspectives. Chem. Soc. Rev. 2016, 45, 6855-6887 .

N. Galy, R. Nguyen, H. Yalgin, N. Thiebault, D. Luart, C. Len. Glycerol in sub- and supercritical solvents. J. Chem. Technol. Biotechnol. 2017, 92, 14-26.

V. Kumar, D. Mathur, Srivastava, S. Malhotra, N. Rana, S.K. Singh, B.K. Singh, A.K. Prasad, A.K. Varma, C Len, R. C. Kuhad, R.K. Saxena, V.S. Parmar. Biocatalytic synthesis of novel partial esters of a bioactive dihydroxy 4-methylcoumarin by  Rhizopus oryzae  lipase (ROL). Molecules 2016, 21, 1499-1509.

S. Le Guenic, D. Gergela, C. Ceballos, F. Delbecq, C. Len. Furfural production from D-xylose and xylan by using stable Nafion NR50 and NaCl in a microwave-assisted biphasic reaction. Molecules 2016, 21, 1102-1112.

A.K. Singh, R. Nguyen, N. Galy, R. Haag, S.K. Sharma, C. Len. Chemo-enzymatic synthesis of oligoglycerol derivatives. Molecules 2016, 21, 1038-1049.

S. Malhotra, M. Tavakkoli, N. Edraki, R. Miri, S.K. Sharma, A.K. Prasad, L. Saso, C. Len, V.S. Parmar and O. Firuzi. Neuroprotective and antioxidant activities of 4-methylcoumarins: Development of structure-activity relationships. Biol. Pharm. Bull. 2016, 39, 1544-1548.

F. Delbecq, Y. Wang, C. Len. Conversion of xylose, xylan and rice husk into furfural via betaine and formic acid mixture as novel homogeneous catalyst in biphasic system by microwave-assisted dehydration. J. Mol. Catal. A: Chemical 2016, 423, 520-525.

C. Cazorla, M. Billamboz, C. Chevrin-Villette, F. Hapiot, E. Monflier, C. Len. Conjugated dienyl derivatives by green bisallylic substitution : synthetic and mechanistic insight. ChemCatChem 2016, 8, 2321-2328.

E. Banaszak-Leonard, F. Mangin, C. Len. Barton decarboxylation under ultrasonic continuous flow. New J. Chem. 2016, 40, 7414-7420.

I. Jioui, K. Danoun, A. Solhy, M. Jouiad, M. Zahouily, B. Essaid, C. Len, A. Fihri. Modified fluorapatite as highly efficient catalyst for the synthesis of chalcones via Claisen-Schmidt condensation reaction. J. Ind. Eng. Chem. 2016, 39, 218-225.

A. Hassine, S. Sebti, A. Solhy, N. Thiebault, B. Essaid, C. Len, A. Fihri. Natural phosphate-supported palladium for hydration of aromatic nitriles to amides in aqueous medium. Curr. Org. Chem. 2016, 20, 2022-2028.

P. Kumar, A.K. Singh, V. Bahadur, C. Len, N.G.J. Richards, V.S. Parmar, E. Van Der Eycken, B.K. Singh. Microwave assisted metal free, base mediated C-N bond formation/cleavage : synthesis of benzimidazo[1,2-a]quinazoline derivatives.  ACS Sustainable Chem. Eng. 2016, 4, 2206-2210.

P.K. Sharma, S.Balwani, D. Mathur, S. Malhotra, B.K. Singh, A.K. Prasad, C. Len, E.V. Van der Eycken, B. Ghosh, V.S. Parmar. Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids. J. Enz. Inhib. Med. Chem. 2016, 31, 1520-1526.

H. Yalgin, D. Luart, C. Len. First examples of Doebner-Miller reaction in flow: Efficient production of 2-methylquinoline derivatives in water. J. Flow Chem. 2016, 6, 80-85.

E. Leonard, F. Mangin, C. Villette, M. Billamboz, C. Len. Azobenzenes and catalysis. Catal. Sci. Technol. 2016, 6, 379-398.

S. Le Guenic, C. Ceballos, C. Len. Simple green dehydration in water : Application to the synthesis of phenylacetaldehyde. J. Mol. Catal. A: Chemical 2016, 411, 72-77.

I. Ouarzki, M. Hazi, D. Luart, C. Len, A. Ould-Driss. Comparison of direct and staged pyrolysis of the ligno-cellulosic biomass with the aim of the production of high added value. J. Mater. Environ. Sci. 2016, 7, 1008-1022.

2015

M. Loth, B. Meddah, A. Tir Touil, C. Len, W. Verstraete. Antifungal activity of synthesized dithiocarbamate derivatives on Fusarium oxysporum f sp. Albedinis in Algeria. J. Chem. Pharm. Res. 2015, 7, 49-54.

S. Le Guenic, F. Delbecq, C. Ceballos, C. Len. Microwave-aided dehydration of D-xylose into furfural by diluted inorganic salts solution in a biphasic system.  J. Mol. Catal. A: Chemical 2015, 410, 1-7.

K. Danoun, I. Jioui, M. Bouhrara, M. Zahouily, A. Solhy, M. Jouiad, C. Len, A. Fihri. Nano-structured pyrophosphate Na 2 CaP 2 O 7 as catalyst for selective synthesis of 1,2-disubstituted benzimidazoles in pure water. Curr. Org. Chem. 2015, 19, 2132-2140.

F. Mangin, E. Banaszak-Léonard, C. Len. One-step Barton decarboxylation by micellar catalysis – application to the synthesis of maleimide derivatives. RSC Adv. 2015, 5, 69616-69620.

S. Le Guenic, C. Ceballos, C. Len. Synthesis of phenylacetaldehyde from 1-phenylethan-1,2-diol by microwave-assisted dehydration in water. Catal. Letters 2015, 145, 1851-1855.

N. Sotto, M. Billamboz, C. Chevrin-Villette, C. Len. Selective pinacol coupling on regenerable supported acids in sole water. J. Org. Chem. 2015, 80, 6375-6380.

M. Billamboz, N. Sotto, C. Chevrin-Villette, C. Len. Simple and expeditious pinacol coupling of non usual a,b-unsaturated carbonyl compounds in water. RSC Adv. 2015, 5, 46026-46030.

M. Kumari, M. Billamboz, E. Leonard, C. Len, C. Böttcher, A.K. Prasad, R. Haag, S.K. Sharma. Self-assembly, photoresponsible behavior and transport potential of azobenzene grafted dendronized polymeric amphiphiles. RSC Adv. 2015, 5, 48301-48310.

H. Saggadi, I. Polaert, D. Luart, C. Len, L. Estel. Microwaves under pressure for the continuous production of quinoline from glycerol. Catalysis Today 2015, 255, 66-74.

G. Herve, C. Len. Aqueous microwaves assisted cross-coupling reactions applied to unprotected nucleosides. Front. Chem. 2015, 3, 10-12.

C. Len, G. Enderlin. Synthesis of C -arylnucleoside analogues. Molecules 2015, 20, 4967-4997.

M. Billamboz, C. Len. First pinacol coupling in emulsified water: key role of surfactant and impact of alternative activation technologies. ChemSusChem 2015, 8, 1664-1675.

G. Kumar, A. Dhawan, B.K. Singh, N.K. Sharma, S.K. Sharma, A.K. Prasad, E.V. Van Der Eycken, C. Len, A.C. Watterson, V.S. Parmar. Highly selective biocatalytic transesterification reactions on aryl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoates. Catal. Lett. 2015, 145, 919-929.

A. Bado-Nilles, A.O. Diallo, G. Marlair, P. Pandard, L. Chabot, A. Geffard, C. Len, J.M. Porcher, W. Sanchez. Coupling of OECD standardized test and immunomarlers to select the most environmentally benign ionic liquid option – Towards an innovative “safety by design” approach. J. Hazard. Mater. 2015, 283, 202-210.

2014

A. Hassine, M. Bouhrara, S. Sebti, A. Solhy, D. Luart, C. Len, A. Fihri. Natural phosphate-supported palladium: a highly efficient and recyclable catalyst for the Suzuki-Miyaura coupling under microwave irradiation. Curr. Org. Chem. 2014, 18, 3141-3148.

T. Lussier, G. Herve, G. Enderlin, C. Len. Original access to 5-aryluracils from 5-iodo-2'-deoxyuridine via a microwave assisted Suzuki-Miyaura cross-coupling/deglycosydation sequence in pure water. RSC Adv. 2014, 4, 46218-46223.

G. Herve, C. Len. First ligand-free microwaves-assisted Heck cross-coupling reaction in sole water on nucleoside – Application to the synthesis of antiviral BVDU. RSC Adv. 2014, 4, 46926-46929.

F. Hamon, C. Blaszkiewicz, M. Buchotte, E. Banaszak-Léonard, H. Bricout, S. Tilloy, E. Monflier, C. Cezard, L. Bouteiller, C. Len, F. Djedaini-Pilard. Synthesis and characterization of a new photo-induced switchable b -cyclodextrin dimer. BeilsteinJ. Org. Chem. 2014, 10, 2874-2885.

O. Amadine, H. Maati, K. Abdelouhadi, A. Fihri, S. El Kazzouli, C. Len, A. El Bouari, A. Solhy. Ceria-supported copper nanoparticles: A highly efficient and recyclable catalyst for N -arylation of indole. J. Mol. Catal. A: Chemical 2014, 395, 409-419.

X. Qiu, C. Len, R. Luque, Y. Li. Solventless oxidative coupling of amines to imines by using transition-metal-free metal-organic frameworks. ChemSusChem 2014, 7, 1684-1688.

H. Saggadi, D. Luart, N. Thiebault, I. Polaert, L. Estel, C. Len. Quinoline and phenanthroline preparation starting from glycerol via improved microwave-assisted modified Skraup reaction. RSC Adv. 2014, 4, 21456-21464.

G. Herve, G. Sartori, G. Enderlin, G. Mackenzie, C. Len. Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides. RSC Adv. 2014, 4, 18558-18594.

P. Kumar, M. Hornum, L.J. Nielsen, G. Enderlin, N.K. Andersen, C. Len, G. Herve, G. Sartori, P. Nielsen. J. Org. Chem. 2014, 79, 2854-2863.

C. Len, R. Luque. Continuous flow transformations of glycerol to valuable products: an overview. Sustainable Chem. Process. 2014, 2, 1-10.

L. Chancelier, A.O. Diallo, C.C. Santini,* G. Marlair, T. Gutel, S. Mailley, C. Len. Targeting adequate thermal stability and fire safety in selecting ionic liquid-based electrolytes for energy storage. Phys. Chem. Chem. Phys. 2014, 16, 1967-1976. Hot article 16 dec 2013

M. Billamboz, F. Mangin, E. Banaszak-Leonard, C. Chevrin Villette, N. Drillaud, C. Len. Micellar catalysis using a photochromic surfactant : application to the Pd-catalysed Tsuji-Trost reaction in water. J. Org. Chem. 2014, 79, 493-500.

H. Saggadi, D. Luart, N. Thiebault, I. Polaert, L. Estel, C. Len. Toward the synthesis of 6-hydroxyquinoline starting from glycerol via improved microwave-assisted modified Skraup reaction. Catal. Commun. 2014, 44, 15-18.

2013

G. Marlair, A.O. Diallo, W. Benaissa, A. Vignes, L. Blanc, C. Len. Developing dedicated methods and tools for safe use and processing of key chemicals in biorefining. Chem. Eng. Trans. 2013, 31, 859-864.

C. Blaszkiewicz, H. Bricout, E. Leonard, C. Len, D. Landy, F. Djedaini-Pilard, E. Monflier, S. Tilloy. A cyclodextrin dimer as supramolecular reaction platform for aqueous organometallic catalysis. Chem. Commun. 2013, 49, 6989-6991.

G. Enderlin, G. Sartori, G. Herve, C. Len. Synthesis of 6-aryluridines via Suzuki-Miyaura cross-coupling reaction at room temperature under aerobic ligand-free conditions in neat water. Tetrahedron Lett. 2013, 54, 3374-3377.

S. Gallagher-Duval, G. Herve, G. Sartori, G. Enderlin, C. Len. Improved microwave-assisted ligand-free Suzuki-Miyaura cross-coupling of 5-iodo-2'-deoxyuridine in pure water. New J. Chem. 2013, 37, 1989-1995.

V. Legros, C. Vanhaverbecke, F. Souard, C. Len, J. Desire. b -Cyclodextrin-glycerol dimmers: their synthesis and NMR conformational analysis. Eur. J. Org. Chem. 2013, 2583-2590.

A.O Diallo, A.B. Morgan, C. Len, G. Marlair. An innovative experimental approach aiming to understand and quantifiy the acual fire hazards of ionic liquids. Energy Environ. Sci. 2013, 6, 699-710.

A. Decottignies, A. Fihri, G. Azemar, F. Djedaini-Pilard, C. Len. Ligandless Suzuki-Miyaura reaction in neat water with or without native b -cyclodextrin as additive. Catal. Commun. 2013, 32, 101-107.

G. Sartori, G. Enderlin, G. Herve, C. Len. New efficient approach of ligand-free Suzuki-Miyaura reaction applied to 5-iodo-2'-deoxyuridine in neat water. Synthesis 2013, 45, 330-333.

A. Hassine, S. Sebti, A Solhy, M. Zahouily, C. Len, M.N. Hedhili, A. Fihri. Palladium Supported on Natural Phosphate: Catalyst for Suzuki Coupling Reactions in Water. Applied Catalysis A: General 2013, 450, 13-18.

2012

R. Delatouche, M. Mondon, F. Collette, C. Bachmann, G. Frapper, C. Len, V. Heroguez, P. Bertrand. Development of new triazolyl-based acidic sensitive releasing systems. Latvian J. Chem. 2012, 1/2, 41-48.

N. Drillaud, E. Banaszac-Leonard, I. Pezron, C. Len. Synthesis and evaluation of photochromic surfactant for organic reactions in aqueous media. J. Org. Chem. 2012, 77, 9553-9561.

J. Boulanger, H. Bricout, S. Tilloy, A. Fihri, C. Len, F. Hapiot, E. Monflier. Water-soluble diphosphadiazacyclooctanes as ligands for aqueous organometallic catalysis. Catal. Commun. 2012, 29, 77-81.

H. Bricout, E. Leonard, C. Len, D. Landy, F. Hapiot, E. Monflier. Impact of cyclodextrins on the behavior of amphiphilic ligands in aqueous organometallic catalysis. Beilstein J. Org. Chem. 2012, 8, 1479-1484.

A.O Diallo, C. Len, A.B. Morgan, G. Marlair. Revisiting phys.-chem. Related safety issues of ionic liquids. Sep. Purif. Technol. 2012, 97, 228-234.

A.O Diallo, G. Fayet, C. Len, G. Marlair. Evaluation of heats of combustion of ionic liquids through use of existing and purpose built models. Ind. Eng. Chem. Res. 2012, 51, 3149-3156.

G. Sartori, G. Enderlin, G. Herve, C. Len. Highly effective synthesis of C-5-substituted 2'-deoxyuridine using Suzuki-Miyaura cross-coupling in water. Synthesis 2012, 44, 767-772.

S. Vuong, N. Brondel, C. Len, S. Papot, B. Renoux. Formal synthesis of TMC 69-6H via a one-pot enantioselective proline-mediated aldol/olefin homologation procedure. Tetrahedron 2012, 68, 433-439.

M. Billamboz, J.C. Legeay, F. Hapiot, E. Monflier, C. Len. Novel strategy for the bis-butenolide synthesis via ring closing metathesis. Synthesis 2012, 44, 137-143.

2011

W. Hatton, J. Hunault, M. Egorov, C. Len, M. Pipelier, V. Blot, V. Silvestre, V. Fargeas, A. Ane, T. McBrayer, M. Detorio, J.H. Cho, N. Bourgougnon, D. Dubreuil, R.F. Schinazi, J. Lebreton Synthesis and Biological Evaluation of 4'-C ,3'-O-Propylene-Linked Bicyclic Nucleosides Eur. J. Org. Chem. 2011, 7390-7399.

N.H. Nguyen, C. Len, A.S. Castanet, J. Mortier. Selectivity in C-alkylation of dianions of protected 6-methyluridine. Beilstein J. Org. Chem. 2011, 7 1228-1233.

R. DeSousa, C. Thurier, C. Len, Y. Pouilloux, J. Barrault, F. Jerome. Regioselective functionalization of glycerol with a dithiocarbamate moiety: an environmentally friendly route to safer fungicides. Green Chem. 2011, 13, 1129-1132.

M. Mondon, R. Delatouche, C. Bachmann, G. Frapper, C. Len, P. Bertrand. Triazolyl Derivatives for acidic release of alcohols. Eur. J. Org. Chem. 2011, 2111-2119.

A. Fihri, D. Luart, C. Len, A. Solhy, C. Chevrin, V. Polshettiwar. Suzuki-Miyaura cross-coupling reactions with low catalyst loading: a green and sustainable protocol in pure water. Dalton Transactions 2011, 40, 3116-3121.

V. Legros, F. Hamon, B. Violeau, F. Turpin, F. Djedaini-Pilard, J. Désiré, C. Len. Toward the supramolecular cyclodextrin dimers using nucleobase pairs. Synthesis 2011, 2, 235-242.

2010

S. Zhong, M. Mondon, C. Len. Synthesis of a novel uridine and its use in attemps to form new cyclonucleosides using ring-closing metathesis. Sc. China Chem. 2010, 53, 1932-1936.

H. Bricout, E. Banaszak, C. Len, F. Hapiot, E. Monflier. Amphiphilic photo-isomerisable phosphanes for aqueous organometallic catalysis. Chem. Commun. 2010, 46, 7813-7815.

C. Lebreton, J.M. Escudier, L. Arzel, C. Len. Synthesis of bicyclonucleosides having a C-C bridge. Chem. Rev. 2010, 110, 3371-3418.

V. Polshettiwar, A. Decottignies, C. Len, A. Fihri. Suzuki-Miyaura cross-coupling in aqueous media: green and sustainable syntheses of biaryl (pNA). ChemSusChem. 2010, 5, 502-522.

S. A. Elfeky, S.E. Flower, N. Masumoto, F. D'Hooge, L. Labarthe, W. Chen, C. Len, T.D. James, J.S. Fossey. Diol appended quenchers for fluorescein boronic acid. Chem. Asian J. 2010, 5, 581-588.

S. Vuong, M.M. Rodriguez-Fernandez, B. Renoux, C. Len. Synthesis of 3-vinyl-2,5-dihydrofuran ring system via enyne metathesis. Carbohydr. Res. 2010, 345, 324-329.

2009

F. Hamon, B. Violeau, F. Turpin, M. Bellot, L. Bouteiller, F. Djedaini-Pilard, C. Len. Potential supramolecular cyclodextrin dimers using nucleobase-pairs. Synlett 2009, 17, 2875-2879.

F. Hamon, F. Djedaini-Pilard, F. Barbot, C. Len. Azobenzenes-Synthesis and carbohydrate application. Tetrahedron 2009, 65, 10105-10123.

V. Polshettiwar, C. Len, A. Fihri. Silica-supported Palladium: Sustainable catalysts for cross-coupling reactions. Coord. Chem. Rev. 2009, 253, 2599-2626.

2008

S. Zhong, M. Mondon, S. Pilard, C. Len. Synthesis and structure of novel cyclonucleoside analogues of uridine. Tetrahedron 2008, 64, 7828-7836.

C. Len, M. Mondon, J. Lebreton. Synthesis of cyclonucleosides having a C-C bridge. Tetrahedron 2008, 64, 7453-7475.

2007

M.M. Rodriguez-Fernandez, S. Vuong, B. Renoux, C. Len. 3-Vinyl-2,5-dihydrofuran derivatives via enyne metathesis. Synlett 2007, 11, 1703-1706.

2006

C. Len. Diatereoisomeric synthesis of novel analogues of d4T having an isochroman glycon moiety. Lett. Org. Chem. 2006, 3, 42-44.

C. Len, G. Mackenzie. Synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides having variations at either or both of the 2'- and 3'-positions. Tetrahedron 2006, 62, 9085-9107.

S. Zhong, M. Mondon, S. Pilard, C. Len. Synthesis of novel dinucleosides via tandem cross metathesis and ring-closing metathesis. Tetrahedron Lett. 2006, 47, 6221-6224.

J. Drone, M. Egorov, W. Hatton, M.-J. Bertrand, C. Len, J. Lebreton. Synthesis of 2',3'-cyclohexen bicyclic uridine analogues using ring-closure metathesis. Synlett 2006, 1339-1342.

C. Len, D. Postel. Synthesis of 2',3'-didehydro-2',3'-dideoxynucleosides via nucleoside route. Current Org. Synth. 2006, 3, 261-281.

E. Lipka, C. Len, C. Rabiller, J.P. Bonte, C. Vaccher. Enantioseparation of cis and trans nucleosides, aromatic analogues of stavudine, by capillary electrophoresis and high-performance liquid chromatography. J. Chromatogr. A 2006, 1132, 141-147.

2005

Lipka, M.P. Vaccher, C. Vaccher, C. Len. Enantiomerical excess determination, puridfication and biological evaluation of (3 S ) and (3 R ) a , b -butenolide analogues of isobenzofuranone. Bioorg. Med. Chem. Lett. 2005, 15, 501-504.

C. Len, B. Violeau. Asymmetric synthesis of thymine nucleoside analogues based on the isochroman core. Tetrahedron Lett. 2005, 46, 4835-4838.

A. Nguyen Van Nhien, C. Tomassi, C. Len, J.L. Marco-Contelles, J. Balzarini, C. Pannecouque, E. De Clercq, D. Postel. First synthesis and evaluation of the inhibitory effects of aza analogues of TSAO on HIV-1 replication. J. Med. Chem. 2005, 48, 4276-4284.

C. Len, S. Pilard, E. Lipka, C. Vaccher, M.P. Dubois, Y. Shrinska, V. Tran, C. Rabiller. Synthesis of diastereo-isomeric pairs of novel analogues of d4T having an isochroman glycon moiety ; their enzymatic kinetic resolution, their enantiopure synthesis, molecular modeling and NMR structural study. Tetrahedron 2005, 61, 10583-10595.

D. F. Ewing, V. Glacon, C. Len, G. Mackenzie. Synthesis, conformation and antiviral activity of nucleoside analogues with the (2-hydroxy-1-phenylethoxy)methyl glycone - a family of nucleoside analogues related to d4T and aciclovir. New J. Chem. 2005, 29, 1461-1468.

2004

A. Nguyen Van Nhien, L. Dominguez, C. Tomassi, M. Rosario Torres, C. Len, D. Postel, J. Marco-Contelles. Synthesis and transformations of [1,2- O -isopropylidene- a -D- erythro (and a - D - ribo )furanose]-3-spiro-3'-(4'-amino-5'H-2',3'-dihydroisothiazole-1,1'-dioxide) derivatives. Tetrahedron 2004, 60, 4709-4727.

E. Lipka, A. Sélouane, D. Postel, C. Len, M.P. Vaccher, J.P. Bonte, C. Vaccher. Enantioseparation of four cis and trans diastereoisomers of d4T analogs, by High Performance Liquid Chromaography and Capillary Electrophoresis. J. Chromatogr. A. 2004, 1034, 161-167.

L. Dominguez, A. Nguyen Van Nhiem, C. Tomassi, C. Len, D. Postel, J.L. Marco-Contelles. Synthesis of 4-amino-5- H -dihydroisothiazole-1,1-dioxide ring system on sugar template via carbanion-mediated sulfonamide intramolecular cyclization reactions (CSIC protocols) of glyco-a-sulfonamidonitriles. J. Org. Chem. 2004, 69, 843-856.

E. Lipka, C. Danel, M.P. Vaccher, V. Glacon, D.F. Ewing, G. Mackenzie, C. Len, J.P. Bonte, C. Vaccher. Enantioseparation of new nucleoside analogs, related to d4T and acyclovir, by chiral capillary electrophoresis using highly sulfated b -cyclodextrine. Electrophoresis 2004, 25, 444-453.

2003

C. Len, G. Mackenzie, D.F. Ewing, G. Sheppard, J. Banoub. Electrospray tandem mass spectrometric analysis of diastereo- and stereoisomeric pyrimidine nucleoside analogues based on the 1,3-dihydrobenzo[c]furan core. Carbohydr. Res. 2003, 338, 2311-2324.

E. Lipka, V. Glacon, G. Mackenzie, D.F. Ewing, C. Len, D. Postel, M.P. Vaccher, J.P. Bonte, C. Vaccher. HPLC separation and determination of enantiomeric purity of novel nucleoside analogues, on cyclodextrin chiral stationary phases using reversed and polar organic modes. Anal. Lett. 2003, 37, 385-398.

D. Egron, C. Périgaud, G. Gosselin, A.M. Aubertin, A. Faraj, A. Sélouane, D. Postel, C. Len. 1,3-Dihydrobenzo[c]furan nucleoside analogues: additional studies of the thymine derivative. Bioorg. Med. Chem. Lett. 2003, 13, 4473-4475.

D.F. Ewing, V. Glaçon, G. Mackenzie, D. Postel, C. Len. Synthesis of acyclic bis-vinyl pyrimidines: a general route to d4T via metathesis. Tetrahedron 2003, 59, 941-945.

C. Len, A. Sélouane, A. Weiling, F. Coicou, D. Postel. Asymmetric synthesis of (3 S) 3-benzoyloxymethylisobenzofuranone and its 3 R enantiomer as analogues of a , b -butenolides. Tetrahedron Lett. 2003, 44, 663-666.

N. Moitessier, C. Henry, C. Len, D. Postel, Y. Chapleur. On the origin of the facial selectivity of the Sharpless Asymmetric Dihydroxylation of styrene derivatives. J. Carbohydr. Chem. 2003, 22, 25-34.

C. Len, A. Sélouane, D. Postel, P. Villa, A.M. Aubertin, D. Egron, G. Gosselin, C. Périgaud. Synthesis, stability and biological evaluation of 1,3-dihydrobenzo[c]furan analogues of d4T and its SATE pronucleotide. Nucleos. Nucleot. Nucleic Acids 2003, 5-8, 943-946.

A. Nguyen Van Nhiem, C. Tomassi, C. Len, J.L. Marco-Contelles, D. Postel. Synthesis of aza analogues of TSAO. Nucleos. Nucleot. Nucleic Acids 2003, 5-8, 939-942.

2002

E. Lipka-Belloli, V. Glaçon, G. Mackenzie, D. Ewing, C. Len, C. Vaccher, J.P. Bonte. Chiral separation of enantiomeric purity of nucleoside analogs to d4T and acyclovir by liquid chromatography, on amylose chiral stationary phases and determination of enantiomeric purity. Chromatographia 2002, 56, 567-572.

E. Lipka-Belloli, V. Glaçon, G. Mackenzie, D. Ewing, C. Len, C. Vaccher, J.P. Bonte. Determination of enantiomeric purity of nucleoside analogs, related to d4T and acyclovir new potential antiviral agents, using HPLC on cellulose chiral stationary phases. J. Chromatogr. A. 2002, 972, 211-219.

N. Moitessier, C. Henry, C. Len, Y. Chapleur. Towards a computational tool predicting the stereochemical outcome of asymmetric reactions. 1. Application to Sharpless asymmetric dihydroxylation. J. Org. Chem. 2002, 67, 7275-7282.

A. Nguyen Van Nhien, H. Ducatel, C. Len, D. Postel. Novel conformationally restricted glycoamino acids from glyco-a-aminonitrile as potent turn mimics in peptide synthesis. Tetrahedron Lett. 2002, 43, 3805-3808.

D. Ewing, V. Glaçon, G. Mackenzie, D. Postel, C. Len. A novel approach to unsaturated acyclic nucleoside analogues and the first synthesis of d4T by ring closure metathesis. Tetrahedron Lett. 2002, 43, 3503-3505.

S. Pilard, D. Riboul, V. Glaçon, N. Moitessier, Y. Chapleur, D. Postel, C. Len. Asymmetric dihydroxylation of chiral styrene derivatives: development of an analytical strategy for the determination of the diastereomeric excess. Tetrahedron: Asymmetry 2002, 13, 529-537.

A. Selouane, C. Vaccher, P. Villa, D. Postel, C. Len. Enantiomeric d4T analogues and their structural determination. Tetrahedron: Asymmetry 2002, 13, 407-413.

D. Ewing, V. Glaçon, G. Mackenzie, C. Len. Asymmetric synthesis of both enantiomers of two acyclic nucleoside analogues related to d4T and acyclovir. Tetrahedron Lett. 2002, 43, 989-991.

D.F. Ewing, V. Glaçon, G. Mackenzie, D. Postel, C. Len. Acyclic nucleoside analogues related to d4T and Acyclovir - Synthesis and conformation. Collection Symposium Series (Z. Tocik and M. Hocek, Eds) 2002, 5, 261-266.

V. Glaçon, D.F. Ewing, G. Mackenzie, D. Postel, C. Len. A novel class of unsaturated acyclic nucleosides and the first synthesis of d4T by ring closure metathesis. Collection Symposium Series (Z. Tocik and M. Hocek, Eds) 2002, 5, 316-318.

2001

E. Belloli, C. Len, G. Mackenzie, G. Ronco, J.P. Bonte, C. Vaccher. Diastereomeric resolution of nucleoside analogues, new potential antiviral agents, using high-performance liquid chromatography on polysaccharide-type chiral stationary phases. J. Chromatogr. A 2001, 943, 91-100.

D.F. Ewing, C. Len, G. Mackenzie, J.P. Petit, G. Ronco, P. Villa. Asymmetric synthesis of aromatic azasaccharide: new potent inhibitors of glycosidases and reverse transcriptase of HIV. J. Pharm. Pharmacol. 2001, 53, 945-948.

C. Len, D. Postel, B. Meddah, P. Villa, G. Ronco. Synthesis of poly(dithio-, thio- and carbamoyl (thio)ester) derivatives of D-glucose. Phosphorus Sulfur Silicon 2001, 173, 59-65.

2000

D.F. Ewing, C. Len, G. Mackenzie, G. Ronco, P. Villa. Asymmetric synthesis of 1,3-dihydrobenzo[ c ]furan derivatives using a D-xylose moiety as a chiral auxiliary. Tetrahedron: Asymmetry 2000, 11, 4995-5002.

D.F. Ewing, N. Fahmi, C. Len, G. Mackenzie, A. Pranzo. Stereoisomeric pyrimidine nucleoside analogues based on the benzo[c]furane core. J. Chem. Soc., Perkin Trans. 1 2000, 21, 3561-3565.

C. Rafin, E. Veignie, M. Sancholle, D. Postel, C. Len, P. Villa, G. Ronco. Synthesis and antifungal activity of novel bisdithiocarbamate derivatives of carbohydrates against Fusarium oxysporum f. sp. Lini. J. Agric. Food Chem. 2000, 48, 5283-5287.

1999

D.F. Ewing, N. Fahmi, C. Len, G. Mackenzie, G. Ronco, P. Villa, G. Shaw. Nucleoside analogues with a novel glycone based on the benzo[c]furan core. Nucleosides Nucleotides 1999, 18, 2613-2630.

C. Len, D. Postel, G. Mackenzie, P. Villa, G. Ronco. Strategy for the preparation of 2' and 3' branched nucleosides. Pharm. Pharmacol. Commun. 1999, 5, 165-168.

1998

C. Len, D. Postel, G. Ronco, P. Villa. Synthesis of dithio-, thio- and carbamoyl ester derivatives of monosaccharides and itols. Phosphorus Sulfur Silicon 1998, 133, 41-59.

1997

C. Len, D. Postel, G. Ronco, P. Villa, C. Goubert, E. Jeufrault, B. Mathon, H. Simon. Synthesis of carbamic esters derivatives of itols: antifungal activity against various crop diseases. J. Agric. Food Chem. 1997, 45, 3-6.

C. Len, D. Postel, G. Ronco, P. Villa. Synthesis of bis(carbamoyl ester) derivatives of D-glucose as antifungal products. J. Carbohydr. Chem. 1997, 16, 1029-1049.

1996

D.F. Ewing, N. Fahmi, C. Len, G. Mackenzie, G. Ronco, P. Villa, G. Shaw. Nucleoside analogues: glycones based on the benzo[c]furan core. Collect. Czech. Chem. Commun. 1996, 61, 145-147.

C. Len, A.S. Merlot, D. Postel, G. Ronco, P. Villa, C. Goubert, E. Jeufrault, B. Mathon, H. Simon. Synthesis and antifungal activity of novel bis(dithiocarbamate) derivatives of glycerol. J. Agric. Food Chem. 1996, 44, 2856-2858.